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1f2u

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{{Seed}}
 
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[[Image:1f2u.png|left|200px]]
 
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<!--
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==Crystal Structure of RAD50 ABC-ATPase==
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The line below this paragraph, containing "STRUCTURE_1f2u", creates the "Structure Box" on the page.
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<StructureSection load='1f2u' size='340' side='right'caption='[[1f2u]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f2u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F2U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1f2u| PDB=1f2u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2u OCA], [https://pdbe.org/1f2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f2u RCSB], [https://www.ebi.ac.uk/pdbsum/1f2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f2u ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF RAD50 ABC-ATPASE===
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== Function ==
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[https://www.uniprot.org/uniprot/RAD50_PYRFU RAD50_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10892749 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f2u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10892749}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1F2U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f2u ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily., Hopfner KP, Karcher A, Shin DS, Craig L, Arthur LM, Carney JP, Tainer JA, Cell. 2000 Jun 23;101(7):789-800. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10892749 10892749]
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</StructureSection>
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[[Category: Protein complex]]
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[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Craig, L.]]
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[[Category: Craig L]]
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[[Category: Hopfner, K P.]]
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[[Category: Hopfner KP]]
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[[Category: Karcher, A.]]
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[[Category: Karcher A]]
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[[Category: Shin, D S.]]
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[[Category: Shin DS]]
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[[Category: Abc-atpase]]
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[[Category: Dna double-strand break repair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:27:35 2008''
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Current revision

Crystal Structure of RAD50 ABC-ATPase

PDB ID 1f2u

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