1f73

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[[Image:1f73.png|left|200px]]
 
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==CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL==
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The line below this paragraph, containing "STRUCTURE_1f73", creates the "Structure Box" on the page.
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<StructureSection load='1f73' size='340' side='right'caption='[[1f73]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F73 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HMN:2,4,6,7,8,9-HEXAHYDROXY-5-METHYLCARBOXAMIDO+NONANOIC+ACID'>HMN</scene></td></tr>
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{{STRUCTURE_1f73| PDB=1f73 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f73 OCA], [https://pdbe.org/1f73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f73 RCSB], [https://www.ebi.ac.uk/pdbsum/1f73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f73 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANA_HAEIN NANA_HAEIN] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/1f73_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f73 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL===
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==See Also==
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*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11031117}}, adds the Publication Abstract to the page
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[[Category: Haemophilus influenzae]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11031117 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Barbosa JARG]]
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{{ABSTRACT_PUBMED_11031117}}
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[[Category: DeGori R]]
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[[Category: Lawrence MC]]
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==About this Structure==
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[[Category: Smith BJ]]
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1F73 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemolphilus_influenzae Haemolphilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F73 OCA].
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==Reference==
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Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme., Barbosa JA, Smith BJ, DeGori R, Ooi HC, Marcuccio SM, Campi EM, Jackson WR, Brossmer R, Sommer M, Lawrence MC, J Mol Biol. 2000 Oct 27;303(3):405-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11031117 11031117]
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[[Category: Haemolphilus influenzae]]
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[[Category: N-acetylneuraminate lyase]]
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[[Category: Single protein]]
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[[Category: Barbosa, J A.R G.]]
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[[Category: DeGori, R.]]
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[[Category: Lawrence, M C.]]
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[[Category: Smith, B J.]]
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[[Category: Beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:48:19 2008''
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Current revision

CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL

PDB ID 1f73

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