1f85

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{{Seed}}
 
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[[Image:1f85.png|left|200px]]
 
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==SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE==
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The line below this paragraph, containing "STRUCTURE_1f85", creates the "Structure Box" on the page.
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<StructureSection load='1f85' size='340' side='right'caption='[[1f85]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f85]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F85 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f85 OCA], [https://pdbe.org/1f85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f85 RCSB], [https://www.ebi.ac.uk/pdbsum/1f85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f85 ProSAT]</span></td></tr>
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{{STRUCTURE_1f85| PDB=1f85 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
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===SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE===
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.,Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890<ref>PMID:11101890</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1f85" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11101890 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11101890}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F85 OCA].
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[[Category: Lancaster AM]]
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[[Category: Lukavsky PJ]]
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==Reference==
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[[Category: Otto GA]]
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101890 11101890]
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[[Category: Puglisi JD]]
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[[Category: Lancaster, A M.]]
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[[Category: Sarnow P]]
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[[Category: Lukavsky, P J.]]
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[[Category: Otto, G A.]]
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[[Category: Puglisi, J D.]]
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[[Category: Sarnow, P.]]
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[[Category: Hairpin loop]]
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[[Category: Hepatitis c virus internal ribosome entry site]]
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[[Category: Ribonucleic acid]]
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[[Category: Rna structure]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:51:03 2008''
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Current revision

SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIIE

PDB ID 1f85

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