1fh5

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{{Seed}}
 
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[[Image:1fh5.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33==
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The line below this paragraph, containing "STRUCTURE_1fh5", creates the "Structure Box" on the page.
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<StructureSection load='1fh5' size='340' side='right'caption='[[1fh5]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fh5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FH5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fh5 OCA], [https://pdbe.org/1fh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fh5 RCSB], [https://www.ebi.ac.uk/pdbsum/1fh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fh5 ProSAT]</span></td></tr>
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{{STRUCTURE_1fh5| PDB=1fh5 | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/1fh5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fh5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Fab fragment of the murine monoclonal antibody, MAK33, directed against human creatine kinase of the muscle-type, was crystallized and the three-dimensional structure was determined to 2.9 A. The antigen-binding surface of MAK33 shows a convex overall shape typical for immunoglobulins binding large antigens. The structure allows us to analyze the environment of cis-prolyl-peptide bonds whose isomerization is of key importance in the folding process. These residues seem to be involved with not only domain stability but also seem to play a role in the association of heavy and light chains, reinforcing the importance of beta-strand recognition in antibody assembly. The structure also allows the localization of segments of primary sequence postulated to represent binding sites for the ER-specific chaperone BiP within the context of the entire Fab fragment. These sequences are found primarily in beta-strands that are necessary for interactions between the individual domains.
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===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33===
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The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip.,Augustine JG, de La Calle A, Knarr G, Buchner J, Frederick CA J Biol Chem. 2001 Feb 2;276(5):3287-94. Epub 2000 Oct 17. PMID:11036070<ref>PMID:11036070</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1fh5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11036070 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11036070}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FH5 OCA].
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[[Category: Mus musculus]]
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[[Category: Augustine JG]]
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==Reference==
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[[Category: Buchner J]]
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The crystal structure of the fab fragment of the monoclonal antibody MAK33. Implications for folding and interaction with the chaperone bip., Augustine JG, de La Calle A, Knarr G, Buchner J, Frederick CA, J Biol Chem. 2001 Feb 2;276(5):3287-94. Epub 2000 Oct 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11036070 11036070]
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[[Category: Frederick CA]]
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[[Category: Augustine, J G.]]
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[[Category: Knarr G]]
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[[Category: Buchner, J.]]
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[[Category: De la Calle A]]
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[[Category: Calle, A de la.]]
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[[Category: Frederick, C A.]]
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[[Category: Knarr, G.]]
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[[Category: Bip]]
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[[Category: Crystal structure]]
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[[Category: Fab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:14:32 2008''
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Current revision

CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE MONOCLONAL ANTIBODY MAK33

PDB ID 1fh5

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