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1fj2

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{{Seed}}
 
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[[Image:1fj2.png|left|200px]]
 
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==Crystal structure of the human acyl protein thioesterase 1 at 1.5 A resolution==
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The line below this paragraph, containing "STRUCTURE_1fj2", creates the "Structure Box" on the page.
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<StructureSection load='1fj2' size='340' side='right'caption='[[1fj2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FJ2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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{{STRUCTURE_1fj2| PDB=1fj2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fj2 OCA], [https://pdbe.org/1fj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fj2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fj2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYPA1_HUMAN LYPA1_HUMAN] Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.<ref>PMID:20418879</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/1fj2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fj2 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the human acyl protein thioesterase 1 at 1.5 A resolution===
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11080636}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11080636 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11080636}}
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==About this Structure==
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1FJ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ2 OCA].
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==Reference==
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Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A., Devedjiev Y, Dauter Z, Kuznetsov SR, Jones TL, Derewenda ZS, Structure. 2000 Nov 15;8(11):1137-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11080636 11080636]
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[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dauter, Z.]]
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[[Category: Dauter Z]]
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[[Category: Derewenda, Z.]]
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[[Category: Derewenda Z]]
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[[Category: Devedjiev, Y.]]
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[[Category: Devedjiev Y]]
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[[Category: Jones, T.]]
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[[Category: Jones T]]
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[[Category: Kuznetsov, S.]]
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[[Category: Kuznetsov S]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Anomalous diffraction]]
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[[Category: Sad]]
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[[Category: Serine hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:20:50 2008''
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Current revision

Crystal structure of the human acyl protein thioesterase 1 at 1.5 A resolution

PDB ID 1fj2

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