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1fjh

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{{Seed}}
 
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[[Image:1fjh.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY==
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The line below this paragraph, containing "STRUCTURE_1fjh", creates the "Structure Box" on the page.
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<StructureSection load='1fjh' size='340' side='right'caption='[[1fjh]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fjh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FJH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fjh OCA], [https://pdbe.org/1fjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fjh RCSB], [https://www.ebi.ac.uk/pdbsum/1fjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fjh ProSAT]</span></td></tr>
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{{STRUCTURE_1fjh| PDB=1fjh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DIDH_COMTE DIDH_COMTE] Catalyzes the reversible interconversion of hydroxy and oxo groups at position 3 of the steroid nucleus. Along with the 3 alpha-hydroxysteroid dehydrogenase and 3-oxo-reductase activities towards a variety of cis or trans fused A/B ring steroids, it also reduces several xenobiotic carbonyl compounds, including a metyrapone-based class of insecticides, to the respective alcohol metabolites. No detectable activity on testosterone, progesterone or 3-oxo-desogestrel.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/1fjh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fjh ConSurf].
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<div style="clear:both"></div>
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===THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY===
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11007791}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11007791 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11007791}}
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==About this Structure==
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1FJH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJH OCA].
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==Reference==
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The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family., Grimm C, Maser E, Mobus E, Klebe G, Reuter K, Ficner R, J Biol Chem. 2000 Dec 29;275(52):41333-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11007791 11007791]
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[[Category: Comamonas testosteroni]]
[[Category: Comamonas testosteroni]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ficner, R.]]
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[[Category: Ficner R]]
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[[Category: Grimm, C.]]
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[[Category: Grimm C]]
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[[Category: Klebe, G.]]
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[[Category: Klebe G]]
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[[Category: Maser, E.]]
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[[Category: Maser E]]
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[[Category: Reuter, K.]]
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[[Category: Reuter K]]
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[[Category: Carbonyl reductase]]
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[[Category: Comamonas testosteroni]]
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[[Category: Hydroxysteroid]]
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[[Category: Metyrapone]]
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[[Category: Oligomerisation]]
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[[Category: Sdr]]
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[[Category: Short chain dehydrogenase]]
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[[Category: Steroid]]
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[[Category: Xenobiotic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:21:47 2008''
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Current revision

THE CRYSTAL STRUCTURE OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY

PDB ID 1fjh

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