1fll

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{{Seed}}
 
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[[Image:1fll.png|left|200px]]
 
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==MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3==
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The line below this paragraph, containing "STRUCTURE_1fll", creates the "Structure Box" on the page.
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<StructureSection load='1fll' size='340' side='right'caption='[[1fll]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fll]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FLL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fll OCA], [https://pdbe.org/1fll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fll RCSB], [https://www.ebi.ac.uk/pdbsum/1fll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fll ProSAT]</span></td></tr>
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{{STRUCTURE_1fll| PDB=1fll | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:[https://omim.org/entry/614849 614849]. A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.<ref>PMID:20832341</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF3_HUMAN TRAF3_HUMAN] Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.<ref>PMID:15383523</ref> <ref>PMID:15084608</ref> <ref>PMID:17991829</ref> <ref>PMID:20097753</ref> <ref>PMID:20185819</ref> <ref>PMID:19937093</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/1fll_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fll ConSurf].
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<div style="clear:both"></div>
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===MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3===
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_10984535}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10984535 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10984535}}
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==About this Structure==
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1FLL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLL OCA].
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==Reference==
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Molecular basis for CD40 signaling mediated by TRAF3., Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR, Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10395-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10984535 10984535]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Chiou, C K.]]
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[[Category: Chiou C-K]]
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[[Category: Ely, K R.]]
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[[Category: Ely KR]]
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[[Category: Leo, E.]]
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[[Category: Leo E]]
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[[Category: Ni, C Z.]]
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[[Category: Ni C-Z]]
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[[Category: Reed, J C.]]
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[[Category: Reed JC]]
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[[Category: Welsh, K.]]
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[[Category: Welsh K]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Tnf signaling]]
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[[Category: Traf3 with cd40 peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:26:48 2008''
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Current revision

MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3

PDB ID 1fll

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