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1fm7

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{{Seed}}
 
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[[Image:1fm7.png|left|200px]]
 
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==CHALCONE ISOMERASE COMPLEXED WITH 5-DEOXYFLAVANONE==
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The line below this paragraph, containing "STRUCTURE_1fm7", creates the "Structure Box" on the page.
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<StructureSection load='1fm7' size='340' side='right'caption='[[1fm7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fm7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DFV:7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE'>DFV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1fm7| PDB=1fm7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fm7 OCA], [https://pdbe.org/1fm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fm7 ProSAT]</span></td></tr>
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</table>
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===CHALCONE ISOMERASE COMPLEXED WITH 5-DEOXYFLAVANONE===
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== Function ==
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[https://www.uniprot.org/uniprot/CFI1_MEDSA CFI1_MEDSA] Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin.<ref>PMID:10966651</ref> <ref>PMID:11955065</ref> <ref>PMID:11698411</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11698411}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11698411 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/1fm7_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11698411}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1FM7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FM7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fm7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Reaction mechanism of chalcone isomerase. pH dependence, diffusion control, and product binding differences., Jez JM, Noel JP, J Biol Chem. 2002 Jan 11;277(2):1361-9. Epub 2001 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11698411 11698411]
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<references/>
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[[Category: Chalcone isomerase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Medicago sativa]]
[[Category: Medicago sativa]]
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[[Category: Single protein]]
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[[Category: Jez JM]]
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[[Category: Jez, J M.]]
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[[Category: Noel JP]]
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[[Category: Noel, J P.]]
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[[Category: Chalcone]]
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[[Category: Diffusion-limited]]
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[[Category: Natural product biosynthesis]]
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[[Category: Plant enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:28:24 2008''
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Current revision

CHALCONE ISOMERASE COMPLEXED WITH 5-DEOXYFLAVANONE

PDB ID 1fm7

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