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1fnl

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{{Seed}}
 
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[[Image:1fnl.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
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The line below this paragraph, containing "STRUCTURE_1fnl", creates the "Structure Box" on the page.
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<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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{{STRUCTURE_1fnl| PDB=1fnl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII===
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== Function ==
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[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11021536}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11021536 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11021536}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1FNL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11021536 11021536]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boesen, C C.]]
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[[Category: Boesen CC]]
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[[Category: Brooks, A G.]]
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[[Category: Brooks AG]]
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[[Category: Fridman, W H.]]
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[[Category: Fridman WH]]
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[[Category: Radaev, S.]]
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[[Category: Radaev S]]
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[[Category: Sautes-Fridman, C.]]
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[[Category: Sautes-Fridman C]]
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[[Category: Sun, P D.]]
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[[Category: Sun PD]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Beta sandwich]]
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[[Category: Immunoglobulin-like]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:37:39 2008''
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Current revision

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

PDB ID 1fnl

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