1foh

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{{Seed}}
 
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[[Image:1foh.png|left|200px]]
 
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==PHENOL HYDROXYLASE FROM TRICHOSPORON CUTANEUM==
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The line below this paragraph, containing "STRUCTURE_1foh", creates the "Structure Box" on the page.
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<StructureSection load='1foh' size='340' side='right'caption='[[1foh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1foh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cutaneotrichosporon_cutaneum Cutaneotrichosporon cutaneum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FOH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene></td></tr>
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{{STRUCTURE_1foh| PDB=1foh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1foh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1foh OCA], [https://pdbe.org/1foh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1foh RCSB], [https://www.ebi.ac.uk/pdbsum/1foh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1foh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHHY_CUTCT PHHY_CUTCT] Hydroxylates phenol to catechol (PubMed:1429434, PubMed:4146224, PubMed:3203745, PubMed:2022646, PubMed:7858421, PubMed:7851397, PubMed:11591156). Phenol is the best substrate, but the enzyme also accepts isomeric diphenols, hydroxyl-, amino-, halogen- or methyl-substituted phenols and, to a lesser degree, cresols (PubMed:4146224, PubMed:17425111, PubMed:7851397).<ref>PMID:11591156</ref> <ref>PMID:1429434</ref> <ref>PMID:17425111</ref> <ref>PMID:2022646</ref> <ref>PMID:3203745</ref> <ref>PMID:4146224</ref> <ref>PMID:7851397</ref> <ref>PMID:7858421</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/1foh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1foh ConSurf].
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<div style="clear:both"></div>
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===PHENOL HYDROXYLASE FROM TRICHOSPORON CUTANEUM===
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9634698}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9634698 is the PubMed ID number.
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</StructureSection>
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[[Category: Cutaneotrichosporon cutaneum]]
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{{ABSTRACT_PUBMED_9634698}}
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[[Category: Large Structures]]
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[[Category: Enroth C]]
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==About this Structure==
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[[Category: Lindqvist Y]]
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1FOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trichosporon_cutaneum Trichosporon cutaneum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FOH OCA].
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[[Category: Neujahr H]]
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[[Category: Schneider G]]
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==Reference==
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The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis., Enroth C, Neujahr H, Schneider G, Lindqvist Y, Structure. 1998 May 15;6(5):605-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9634698 9634698]
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[[Category: Phenol 2-monooxygenase]]
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[[Category: Single protein]]
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[[Category: Trichosporon cutaneum]]
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[[Category: Enroth, C.]]
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[[Category: Lindqvist, Y.]]
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[[Category: Neujahr, H.]]
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[[Category: Schneider, G.]]
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[[Category: Flavin]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Phenol hydroxylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:41:01 2008''
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Current revision

PHENOL HYDROXYLASE FROM TRICHOSPORON CUTANEUM

PDB ID 1foh

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