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1fq8

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{{Seed}}
 
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[[Image:1fq8.png|left|200px]]
 
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==X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN==
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The line below this paragraph, containing "STRUCTURE_1fq8", creates the "Structure Box" on the page.
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<StructureSection load='1fq8' size='340' side='right'caption='[[1fq8]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FQ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2Y4:N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-CYCLOHEXYL-4,4-DIFLUORO-3-HYDROXY-5-(METHYLAMINO)-5-OXO-PENTAN-2-YL]AMINO]-1-OXO-HEXAN-2-YL]AMINO]-1-OXO-3-PHENYL-PROPAN-2-YL]MORPHOLINE-4-CARBOXAMIDE'>2Y4</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1fq8| PDB=1fq8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fq8 OCA], [https://pdbe.org/1fq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fq8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CARP_YEAST CARP_YEAST] Aspartyl protease implicated in the post-translational regulation of S.cerevisiae vacuolar proteinases. Acts on YSCB, on YSCY and on itself.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/1fq8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fq8 ConSurf].
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<div style="clear:both"></div>
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===X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN===
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==See Also==
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*[[Pepsin|Pepsin]]
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 11061973 is the PubMed ID number.
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[[Category: Large Structures]]
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-->
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{{ABSTRACT_PUBMED_11061973}}
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==About this Structure==
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1FQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ8 OCA].
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==Reference==
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X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity., Cronin NB, Badasso MO, J Tickle I, Dreyer T, Hoover DJ, Rosati RL, Humblet CC, Lunney EA, Cooper JB, J Mol Biol. 2000 Nov 10;303(5):745-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11061973 11061973]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Saccharopepsin]]
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[[Category: Badasso MO]]
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[[Category: Single protein]]
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[[Category: Cooper JB]]
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[[Category: Badasso, M O.]]
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[[Category: Cronin NB]]
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[[Category: Cooper, J B.]]
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[[Category: Dreyer T]]
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[[Category: Cronin, N B.]]
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[[Category: Hoover DJ]]
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[[Category: Dreyer, T.]]
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[[Category: Humblet CC]]
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[[Category: Hoover, D J.]]
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[[Category: Lunney EA]]
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[[Category: Humblet, C C.]]
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[[Category: Rosati RL]]
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[[Category: Lunney, E A.]]
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[[Category: Tickle IJ]]
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[[Category: Rosati, R L.]]
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[[Category: Tickle, I J.]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:46:23 2008''
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Current revision

X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN

PDB ID 1fq8

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