This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:17, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1fqk.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]==
-
The line below this paragraph, containing "STRUCTURE_1fqk", creates the "Structure Box" on the page.
+
<StructureSection load='1fqk' size='340' side='right'caption='[[1fqk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1fqk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FQK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_1fqk| PDB=1fqk | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fqk OCA], [https://pdbe.org/1fqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fqk RCSB], [https://www.ebi.ac.uk/pdbsum/1fqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fqk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/1fqk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fqk ConSurf].
 +
<div style="clear:both"></div>
-
===CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]===
+
==See Also==
-
 
+
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
-
 
+
*[[Transducin 3D structures|Transducin 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_11234020}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11234020 is the PubMed ID number.
+
__TOC__
-
-->
+
</StructureSection>
-
{{ABSTRACT_PUBMED_11234020}}
+
-
 
+
-
==About this Structure==
+
-
1FQK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus_and_rattus_norvegicus Bos taurus and rattus norvegicus] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQK OCA].
+
-
 
+
-
==Reference==
+
-
Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A., Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB, Nature. 2001 Feb 22;409(6823):1071-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11234020 11234020]
+
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Bos taurus and rattus norvegicus]]
+
[[Category: Large Structures]]
-
[[Category: Protein complex]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Cowan, C W.]]
+
[[Category: Cowan CW]]
-
[[Category: He, W.]]
+
[[Category: He W]]
-
[[Category: Kercher, M A.]]
+
[[Category: Kercher MA]]
-
[[Category: Sigler, P B.]]
+
[[Category: Sigler PB]]
-
[[Category: Slep, K C.]]
+
[[Category: Slep KC]]
-
[[Category: Wensel, T G.]]
+
[[Category: Wensel TG]]
-
[[Category: G protein]]
+
-
[[Category: Gap]]
+
-
[[Category: Phototransduction]]
+
-
[[Category: Rg]]
+
-
[[Category: Rgs9]]
+
-
[[Category: Rod]]
+
-
[[Category: Transducin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:47:21 2008''
+

Current revision

CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]

PDB ID 1fqk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fqk"
Personal tools