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1fs4

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{{Seed}}
 
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[[Image:1fs4.png|left|200px]]
 
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==Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design==
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The line below this paragraph, containing "STRUCTURE_1fs4", creates the "Structure Box" on the page.
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<StructureSection load='1fs4' size='340' side='right'caption='[[1fs4]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fs4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FS4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRA:1-DEOXY-1-METHOXYCARBAMIDO-BETA-D-GLUCO-2-HEPTULOPYRANOSONAMIDE'>CRA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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{{STRUCTURE_1fs4| PDB=1fs4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fs4 OCA], [https://pdbe.org/1fs4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fs4 RCSB], [https://www.ebi.ac.uk/pdbsum/1fs4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fs4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fs4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fs4 ConSurf].
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<div style="clear:both"></div>
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===Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design===
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==See Also==
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*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16222658}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16222658 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16222658}}
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==About this Structure==
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1FS4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FS4 OCA].
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==Reference==
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Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase., Watson KA, Chrysina ED, Tsitsanou KE, Zographos SE, Archontis G, Fleet GW, Oikonomakos NG, Proteins. 2005 Dec 1;61(4):966-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16222658 16222658]
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Phosphorylase]]
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[[Category: Fleet GW]]
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[[Category: Single protein]]
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[[Category: Gregoriou M]]
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[[Category: Fleet, G W.]]
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[[Category: Johnson LN]]
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[[Category: Gregoriou, M.]]
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[[Category: Oikonomakos NG]]
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[[Category: Johnson, L N.]]
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[[Category: Skamnaki VT]]
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[[Category: Oikonomakos, N G.]]
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[[Category: Tsitsanou KE]]
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[[Category: Skamnaki, V T.]]
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[[Category: Watson KA]]
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[[Category: Tsitsanou, K E.]]
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[[Category: Zographos SE]]
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[[Category: Watson, K A.]]
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[[Category: Zographos, S E.]]
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[[Category: Enzyme-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:51:41 2008''
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Current revision

Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design

PDB ID 1fs4

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