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1fsw

From Proteopedia

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{{Seed}}
 
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[[Image:1fsw.png|left|200px]]
 
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<!--
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==AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CEPHALOTHINBORONIC ACID==
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The line below this paragraph, containing "STRUCTURE_1fsw", creates the "Structure Box" on the page.
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<StructureSection load='1fsw' size='340' side='right'caption='[[1fsw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fsw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FSW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTB:N-2-THIOPHEN-2-YL-ACETAMIDE+BORONIC+ACID'>CTB</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1fsw| PDB=1fsw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fsw OCA], [https://pdbe.org/1fsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fsw RCSB], [https://www.ebi.ac.uk/pdbsum/1fsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fsw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fsw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fsw ConSurf].
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<div style="clear:both"></div>
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===AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CEPHALOTHINBORONIC ACID===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11182316}}, adds the Publication Abstract to the page
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[[Category: Escherichia coli K-12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11182316 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Blaszczak LC]]
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{{ABSTRACT_PUBMED_11182316}}
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[[Category: Caselli E]]
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[[Category: Powers RA]]
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==About this Structure==
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[[Category: Prati F]]
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1FSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSW OCA].
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[[Category: Shoichet BK]]
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[[Category: Wu CY]]
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==Reference==
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Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases., Caselli E, Powers RA, Blasczcak LC, Wu CY, Prati F, Shoichet BK, Chem Biol. 2001 Jan;8(1):17-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11182316 11182316]
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[[Category: Beta-lactamase]]
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[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Blaszczak, L C.]]
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[[Category: Caselli, E.]]
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[[Category: Powers, R A.]]
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[[Category: Prati, F.]]
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[[Category: Shoichet, B K.]]
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[[Category: Wu, C Y.]]
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[[Category: Beta-lactamase]]
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[[Category: Cephalosporinase]]
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[[Category: Serine hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:53:51 2008''
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Current revision

AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CEPHALOTHINBORONIC ACID

PDB ID 1fsw

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