1fwk

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{{Seed}}
 
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[[Image:1fwk.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP==
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The line below this paragraph, containing "STRUCTURE_1fwk", creates the "Structure Box" on the page.
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<StructureSection load='1fwk' size='340' side='right'caption='[[1fwk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fwk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FWK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1fwk| PDB=1fwk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fwk OCA], [https://pdbe.org/1fwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fwk RCSB], [https://www.ebi.ac.uk/pdbsum/1fwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fwk ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP===
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== Function ==
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[https://www.uniprot.org/uniprot/KHSE_METJA KHSE_METJA] Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11188689}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11188689 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/1fwk_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11188689}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1FWK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fwk ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily., Zhou T, Daugherty M, Grishin NV, Osterman AL, Zhang H, Structure. 2000 Dec 15;8(12):1247-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11188689 11188689]
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</StructureSection>
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[[Category: Homoserine kinase]]
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Daugherty M]]
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[[Category: Daugherty, M.]]
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[[Category: Grishin NV]]
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[[Category: Grishin, N V.]]
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[[Category: Osterman AL]]
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[[Category: Osterman, A L.]]
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[[Category: Zhang H]]
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[[Category: Zhang, H.]]
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[[Category: Zhou T]]
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[[Category: Zhou, T.]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:03:08 2008''
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Current revision

CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ADP

PDB ID 1fwk

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