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1fwz

From Proteopedia

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{{Seed}}
 
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[[Image:1fwz.png|left|200px]]
 
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<!--
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==GLU20ALA DTXR==
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The line below this paragraph, containing "STRUCTURE_1fwz", creates the "Structure Box" on the page.
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<StructureSection load='1fwz' size='340' side='right'caption='[[1fwz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FWZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1fwz| PDB=1fwz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fwz OCA], [https://pdbe.org/1fwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fwz RCSB], [https://www.ebi.ac.uk/pdbsum/1fwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fwz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DTXR_CORDI DTXR_CORDI] Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression. Represses ripA under iron excess.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/1fwz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fwz ConSurf].
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<div style="clear:both"></div>
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===GLU20ALA DTXR===
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==See Also==
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*[[Diphtheria toxin repressor|Diphtheria toxin repressor]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11320302}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11320302 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11320302}}
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==About this Structure==
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1FWZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWZ OCA].
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==Reference==
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Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity., Pohl E, Goranson-Siekierke J, Choi MK, Roosild T, Holmes RK, Hol WG, Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):619-27. Epub 2001, Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11320302 11320302]
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[[Category: Corynebacterium diphtheriae]]
[[Category: Corynebacterium diphtheriae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Goranson-Siekierke, J.]]
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[[Category: Goranson-Siekierke J]]
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[[Category: Hol, W G.J.]]
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[[Category: Hol WGJ]]
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[[Category: Holmes, R K.]]
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[[Category: Holmes RK]]
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[[Category: Pohl, E.]]
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[[Category: Pohl E]]
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[[Category: Dna binding protein]]
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[[Category: Metal binding protein]]
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[[Category: Regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:04:17 2008''
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Current revision

GLU20ALA DTXR

PDB ID 1fwz

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