1fyc

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{{Seed}}
 
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[[Image:1fyc.png|left|200px]]
 
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==INNER LIPOYL DOMAIN FROM HUMAN PYRUVATE DEHYDROGENASE (PDH) COMPLEX, NMR, 1 STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1fyc", creates the "Structure Box" on the page.
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<StructureSection load='1fyc' size='340' side='right'caption='[[1fyc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fyc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyc OCA], [https://pdbe.org/1fyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyc RCSB], [https://www.ebi.ac.uk/pdbsum/1fyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyc ProSAT]</span></td></tr>
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{{STRUCTURE_1fyc| PDB=1fyc | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ODP2_HUMAN ODP2_HUMAN] Note=Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantibodies against the E2 component of pyruvate dehydrogenase complex. Defects in DLAT are the cause of pyruvate dehydrogenase E2 deficiency (PDHE2 deficiency) [MIM:[https://omim.org/entry/245348 245348]; also known as lactic acidemia due to defect of E2 lipoyl transacetylase of the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. In this form of PDH deficiency episodic dystonia is the major neurological manifestation, with other more common features of pyruvate dehydrogenase deficiency, such as hypotonia and ataxia, being less prominent.
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== Function ==
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[https://www.uniprot.org/uniprot/ODP2_HUMAN ODP2_HUMAN] The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyc ConSurf].
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<div style="clear:both"></div>
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===INNER LIPOYL DOMAIN FROM HUMAN PYRUVATE DEHYDROGENASE (PDH) COMPLEX, NMR, 1 STRUCTURE===
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==See Also==
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*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]]
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*[[Dihydrolipoamide acetyltransferase 3D structures|Dihydrolipoamide acetyltransferase 3D structures]]
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 9649469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9649469}}
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==About this Structure==
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1FYC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYC OCA].
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==Reference==
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Three-dimensional structure of the major autoantigen in primary biliary cirrhosis., Howard MJ, Fuller C, Broadhurst RW, Perham RN, Tang JG, Quinn J, Diamond AG, Yeaman SJ, Gastroenterology. 1998 Jul;115(1):139-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9649469 9649469]
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[[Category: Dihydrolipoyllysine-residue acetyltransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Broadhurst, R W.]]
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[[Category: Broadhurst RW]]
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[[Category: Fuller, C.]]
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[[Category: Fuller C]]
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[[Category: Howard, M J.]]
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[[Category: Howard MJ]]
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[[Category: Perham, R N.]]
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[[Category: Perham RN]]
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[[Category: Quinn, J.]]
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[[Category: Quinn J]]
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[[Category: Yeaman, S J.]]
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[[Category: Yeaman SJ]]
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[[Category: Acyltransferase dihydrolipoamide]]
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[[Category: Subunit]]
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[[Category: Transferase]]
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[[Category: Unlipoylated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:07:35 2008''
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Current revision

INNER LIPOYL DOMAIN FROM HUMAN PYRUVATE DEHYDROGENASE (PDH) COMPLEX, NMR, 1 STRUCTURE

PDB ID 1fyc

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