1fyo

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{{Seed}}
 
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[[Image:1fyo.png|left|200px]]
 
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==EUKARYOTIC DECODING REGION A-SITE RNA==
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The line below this paragraph, containing "STRUCTURE_1fyo", creates the "Structure Box" on the page.
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<StructureSection load='1fyo' size='340' side='right'caption='[[1fyo]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fyo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyo OCA], [https://pdbe.org/1fyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyo RCSB], [https://www.ebi.ac.uk/pdbsum/1fyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyo ProSAT]</span></td></tr>
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{{STRUCTURE_1fyo| PDB=1fyo | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The aminoglycoside antibiotics target a region of highly conserved nucleotides in the aminoacyl-tRNA site (A site) of 16 S RNA on the 30 S subunit. The structures of a prokaryotic decoding region A-site oligonucleotide free in solution and bound to the aminoglycosides paromomycin and gentamicin C1A have been determined. Here, the structure of a eukaryotic decoding region A-site oligonucleotide has been determined using homonuclear and heteronuclear NMR spectroscopy, and compared to the unbound prokaryotic rRNA structure. The two structures are similar, with a U1406-U1495 base-pair, a C1407-G1494 Watson-Crick base-pair, and a G1408-A1493 base-pair instead of the A1408-A1493 base-pair of the prokaryotic structure. The two structures differ in the orientation of the 1408 position with respect to A1493; G1408 is rotated toward the major groove, which is the binding pocket for aminoglycosides. The structures also differ in the stacking geometry of G1494 on A1493, which could have slight long-range conformational effects.
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===EUKARYOTIC DECODING REGION A-SITE RNA===
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Structure of a eukaryotic decoding region A-site RNA.,Lynch SR, Puglisi JD J Mol Biol. 2001 Mar 9;306(5):1023-35. PMID:11237616<ref>PMID:11237616</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_11237616}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1fyo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11237616 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11237616}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].
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[[Category: Lynch SR]]
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[[Category: Puglisi JD]]
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==Reference==
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Structure of a eukaryotic decoding region A-site RNA., Lynch SR, Puglisi JD, J Mol Biol. 2001 Mar 9;306(5):1023-35. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11237616 11237616]
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[[Category: Lynch, S R.]]
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[[Category: Puglisi, J D.]]
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[[Category: Bulged some]]
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[[Category: G-a base pair]]
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[[Category: Stem-internal loop-stem-tetraloop rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:25 2008''
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Current revision

EUKARYOTIC DECODING REGION A-SITE RNA

PDB ID 1fyo

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