1g39

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{{Seed}}
 
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[[Image:1g39.png|left|200px]]
 
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==WILD-TYPE HNF-1ALPHA DIMERIZATION DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1g39", creates the "Structure Box" on the page.
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<StructureSection load='1g39' size='340' side='right'caption='[[1g39]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g39]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G39 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.22&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g39 OCA], [https://pdbe.org/1g39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g39 RCSB], [https://www.ebi.ac.uk/pdbsum/1g39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g39 ProSAT]</span></td></tr>
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{{STRUCTURE_1g39| PDB=1g39 | SCENE= }}
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</table>
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== Function ==
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===WILD-TYPE HNF-1ALPHA DIMERIZATION DOMAIN===
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[https://www.uniprot.org/uniprot/HNF1A_MOUSE HNF1A_MOUSE] Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.<ref>PMID:19289501</ref> <ref>PMID:10966642</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 11106484 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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{{ABSTRACT_PUBMED_11106484}}
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[[Category: Alber T]]
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[[Category: Cronk JD]]
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==About this Structure==
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[[Category: Endrizzi JA]]
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1G39 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G39 OCA].
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[[Category: Holton J]]
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[[Category: Rose RB]]
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==Reference==
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High-resolution structure of the HNF-1alpha dimerization domain., Rose RB, Endrizzi JA, Cronk JD, Holton J, Alber T, Biochemistry. 2000 Dec 12;39(49):15062-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11106484 11106484]
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[[Category: Single protein]]
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[[Category: Alber, T.]]
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[[Category: Cronk, J D.]]
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[[Category: Endrizzi, J A.]]
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[[Category: Holton, J.]]
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[[Category: Rose, R B.]]
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[[Category: Dimerization domain]]
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[[Category: Four-helix bundle]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:20:50 2008''
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Current revision

WILD-TYPE HNF-1ALPHA DIMERIZATION DOMAIN

PDB ID 1g39

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