1fue

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(New page: 200px<br /><applet load="1fue" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fue, resolution 2.40&Aring;" /> '''FLAVODOXIN FROM HELI...)
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[[Image:1fue.gif|left|200px]]<br /><applet load="1fue" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fue, resolution 2.40&Aring;" />
 
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'''FLAVODOXIN FROM HELICOBACTER PYLORI'''<br />
 
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==Overview==
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==FLAVODOXIN FROM HELICOBACTER PYLORI==
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The redox protein flavodoxin has been shown earlier to be reduced by the, pyruvate-oxidoreductase (POR) enzyme complex of Helicobacter pylori, and, also was proposed to be involved in the pathogenesis of gastric, mucosa-associated lymphoid-tissue lymphoma (MALToma). Here, we report its, X-ray structure, which is similar to flavodoxins of other bacteria and, cyanobacteria. However, H. pylori flavodoxin has an alanine residue near, the isoalloxazine ring of its cofactor flavin mononucleotide (FMN), while, the other previously crystallized flavodoxins have a larger hydrophobic, residue at this position. This creates a solute filled hole near the FMN, cofactor of H. pylori flavodoxin. We also show that flavodoxin is, essential for the survival of H. pylori, and conclude that its structure, can be used as a starting point for the modeling of an inhibitor for the, interaction between the POR-enzyme complex and flavodoxin.
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<StructureSection load='1fue' size='340' side='right'caption='[[1fue]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FUE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fue OCA], [https://pdbe.org/1fue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fue RCSB], [https://www.ebi.ac.uk/pdbsum/1fue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fue ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLAV_HELPJ FLAV_HELPJ] Low-potential electron donor to a number of redox enzymes (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/1fue_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fue ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1FUE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with FMN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FUE OCA].
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*[[Flavodoxin 3D structures|Flavodoxin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori., Freigang J, Diederichs K, Schafer KP, Welte W, Paul R, Protein Sci. 2002 Feb;11(2):253-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11790835 11790835]
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[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Diederichs, K.]]
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[[Category: Diederichs K]]
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[[Category: Freigang, J.]]
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[[Category: Freigang J]]
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[[Category: Paul, R.]]
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[[Category: Paul R]]
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[[Category: Schaefer, K.P.]]
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[[Category: Schaefer KP]]
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[[Category: Welte, W.]]
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[[Category: Welte W]]
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[[Category: FMN]]
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[[Category: flavoprotein]]
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[[Category: fmn]]
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[[Category: helicobacter pylori]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:17:49 2007''
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Current revision

FLAVODOXIN FROM HELICOBACTER PYLORI

PDB ID 1fue

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