1g92

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{{Seed}}
 
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[[Image:1g92.png|left|200px]]
 
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==SOLUTION STRUCTURE OF PONERATOXIN==
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The line below this paragraph, containing "STRUCTURE_1g92", creates the "Structure Box" on the page.
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<StructureSection load='1g92' size='340' side='right'caption='[[1g92]]' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paraponera_clavata Paraponera clavata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G92 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g92 OCA], [https://pdbe.org/1g92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g92 RCSB], [https://www.ebi.ac.uk/pdbsum/1g92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g92 ProSAT]</span></td></tr>
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{{STRUCTURE_1g92| PDB=1g92 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TX1A_PARCV TX1A_PARCV] Blocks nicotinic synaptic transmission in insect CNS and affects voltage-gated sodium channels (Nav). It is a strong, but very slowly acting agonist for smooth muscles and its blocks synaptic transmission in the insect CNS in a concentration-dependent manner and depolarizes giant interneurons. Also affects neuromuscular transmission in rat tissue.<ref>PMID:12097919</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Poneratoxin is a small neuropeptide found in the venom of the ant Paraponera clavata. It is stored in the venom reservoir as an inactive 25-residue peptide. Here we describe both chemically synthesized poneratoxin and poneratoxin obtained by expression in insect cells. When expressed in insect cells, poneratoxin was observed attached to cell membranes. Both synthetic and recombinant ponerotoxins were soluble below pH 4.5. The structure of synthetic poneratoxin was characterized by circular dichroism and solved by nuclear magnetic resonance. In an environment imitating a lipid bilayer, at pH within the range of insect hemolymph, synthetic poneratoxin has a V shape, with two alpha-helices connected by a beta-turn. Insect larvae were paralyzed by injection of either of the purified toxins, with the recombinant one acting faster. The recombinant toxin-producing baculovirus reduced the average survival time of the insect host by 25 h compared with unmodified virus. Mass spectrometry analysis showed that the recombinant toxin has an N-terminal 21-residue extension, possibly improving its stability and/or stabilizing the membrane-bound state. The potential use of poneratoxin for the construction of biological insecticide is discussed.
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===SOLUTION STRUCTURE OF PONERATOXIN===
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Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide.,Szolajska E, Poznanski J, Ferber ML, Michalik J, Gout E, Fender P, Bailly I, Dublet B, Chroboczek J Eur J Biochem. 2004 Jun;271(11):2127-36. PMID:15153103<ref>PMID:15153103</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15153103}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1g92" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15153103 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15153103}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1G92 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G92 OCA].
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[[Category: Paraponera clavata]]
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[[Category: Bailly I]]
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==Reference==
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[[Category: Chroboczek J]]
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Poneratoxin, a neurotoxin from ant venom. Structure and expression in insect cells and construction of a bio-insecticide., Szolajska E, Poznanski J, Ferber ML, Michalik J, Gout E, Fender P, Bailly I, Dublet B, Chroboczek J, Eur J Biochem. 2004 Jun;271(11):2127-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15153103 15153103]
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[[Category: Dublet B]]
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[[Category: Single protein]]
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[[Category: Fender P]]
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[[Category: Bailly, I.]]
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[[Category: Ferber ML]]
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[[Category: Chroboczek, J.]]
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[[Category: Gout E]]
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[[Category: Dublet, B.]]
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[[Category: Michalik J]]
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[[Category: Fender, P.]]
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[[Category: Poznanski J]]
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[[Category: Ferber, M L.]]
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[[Category: Szolajska E]]
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[[Category: Gout, E.]]
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[[Category: Michalik, J.]]
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[[Category: Poznanski, J.]]
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[[Category: Szolajska, E.]]
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[[Category: Neurotoxin]]
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[[Category: Sodium channel inhibitor]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:54:33 2008''
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Current revision

SOLUTION STRUCTURE OF PONERATOXIN

PDB ID 1g92

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