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1g9t

From Proteopedia

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{{Seed}}
 
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[[Image:1g9t.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1g9t", creates the "Structure Box" on the page.
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<StructureSection load='1g9t' size='340' side='right'caption='[[1g9t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G9T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene></td></tr>
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{{STRUCTURE_1g9t| PDB=1g9t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g9t OCA], [https://pdbe.org/1g9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g9t RCSB], [https://www.ebi.ac.uk/pdbsum/1g9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g9t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPRT_ECOLI HPRT_ECOLI] Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/1g9t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g9t ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX===
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12070315}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12070315 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12070315}}
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==About this Structure==
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1G9T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G9T OCA].
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==Reference==
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Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase., Guddat LW, Vos S, Martin JL, Keough DT, de Jersey J, Protein Sci. 2002 Jul;11(7):1626-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12070315 12070315]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hypoxanthine phosphoribosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Guddat LW]]
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[[Category: Guddat, L W.]]
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[[Category: Martin JL]]
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[[Category: Jersey, J de.]]
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[[Category: Vos S]]
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[[Category: Martin, J L.]]
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[[Category: De Jersey J]]
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[[Category: Vos, S.]]
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[[Category: Keough DT]]
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[[Category: Keough, D T.]]
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[[Category: Crystal structure]]
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[[Category: Enzymology]]
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[[Category: Phosphoribosyltransferase]]
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[[Category: Protein chemistry]]
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[[Category: Purine salvage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:57:45 2008''
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Current revision

CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX

PDB ID 1g9t

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