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1gat

From Proteopedia

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{{Seed}}
 
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[[Image:1gat.png|left|200px]]
 
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<!--
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==SOLUTION STRUCTURE OF THE SPECIFIC DNA COMPLEX OF THE ZINC CONTAINING DNA BINDING DOMAIN OF THE ERYTHROID TRANSCRIPTION FACTOR GATA-1 BY MULTIDIMENSIONAL NMR==
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The line below this paragraph, containing "STRUCTURE_1gat", creates the "Structure Box" on the page.
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<StructureSection load='1gat' size='340' side='right'caption='[[1gat]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gat]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GAT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1gat| PDB=1gat | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gat OCA], [https://pdbe.org/1gat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gat RCSB], [https://www.ebi.ac.uk/pdbsum/1gat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gat ProSAT]</span></td></tr>
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</table>
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===SOLUTION STRUCTURE OF THE SPECIFIC DNA COMPLEX OF THE ZINC CONTAINING DNA BINDING DOMAIN OF THE ERYTHROID TRANSCRIPTION FACTOR GATA-1 BY MULTIDIMENSIONAL NMR===
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== Function ==
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[https://www.uniprot.org/uniprot/GATA1_CHICK GATA1_CHICK] Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_1567844}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 1567844 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/1gat_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_1567844}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1GAT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GAT OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gat ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1., Omichinski JG, Clore GM, Robien M, Sakaguchi K, Appella E, Gronenborn AM, Biochemistry. 1992 Apr 28;31(16):3907-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1567844 1567844]
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</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Clore, G M.]]
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[[Category: Clore GM]]
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[[Category: Gronenborn, A M.]]
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[[Category: Gronenborn AM]]
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[[Category: Omichinski, J G.]]
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[[Category: Omichinski JG]]
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[[Category: Dna]]
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[[Category: Dna/transcription factor complex]]
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[[Category: Double helix]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:00:26 2008''
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Current revision

SOLUTION STRUCTURE OF THE SPECIFIC DNA COMPLEX OF THE ZINC CONTAINING DNA BINDING DOMAIN OF THE ERYTHROID TRANSCRIPTION FACTOR GATA-1 BY MULTIDIMENSIONAL NMR

PDB ID 1gat

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