1ggz

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{{Seed}}
 
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[[Image:1ggz.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS==
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The line below this paragraph, containing "STRUCTURE_1ggz", creates the "Structure Box" on the page.
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<StructureSection load='1ggz' size='340' side='right'caption='[[1ggz]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ggz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GGZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1ggz| PDB=1ggz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ggz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ggz OCA], [https://pdbe.org/1ggz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ggz RCSB], [https://www.ebi.ac.uk/pdbsum/1ggz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ggz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CALL3_HUMAN CALL3_HUMAN] May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/1ggz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ggz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A calmodulin (CaM)-like protein (hCLP) is expressed in human mammary epithelial cells but appears to be limited to certain epithelial cells such as those found in skin, prostate, breast and cervical tissues. A decrease in the expression of this protein is associated with the occurrence of tumors in breast epithelium. The structure of hCLP determined to 1.5 A resolution by X-ray crystallography shows a distinct 30 degrees displacement along the interconnecting central helix, when compared to the highly conserved structure of vertebrate CaM, resulting in a difference in the relative orientation of its two globular domains. Additionally, the electric surface potential landscape at the target protein binding regions on the two globular domains of hCLP is significantly different from those of CaM, indicating that the respective ranges of hCLP and hCaM target proteins do not fully overlap. Observations that hCLP can competitively inhibit CaM activation of target proteins also imply a role for hCLP in which it may also serve as a modulator of CaM activity in the epithelial cells where hCLP is expressed.
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===CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS===
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Crystal structure of human calmodulin-like protein: insights into its functional role.,Han BG, Han M, Sui H, Yaswen P, Walian PJ, Jap BK FEBS Lett. 2002 Jun 19;521(1-3):24-30. PMID:12067719<ref>PMID:12067719</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12067719}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1ggz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12067719 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12067719}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GGZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GGZ OCA].
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==Reference==
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Crystal structure of human calmodulin-like protein: insights into its functional role., Han BG, Han M, Sui H, Yaswen P, Walian PJ, Jap BK, FEBS Lett. 2002 Jun 19;521(1-3):24-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12067719 12067719]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Han, B G.]]
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[[Category: Han B-G]]
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[[Category: Han, M.]]
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[[Category: Han M]]
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[[Category: Jap, B K.]]
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[[Category: Jap BK]]
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[[Category: Sui, H.]]
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[[Category: Sui H]]
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[[Category: Walian, P J.]]
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[[Category: Walian PJ]]
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[[Category: Yaswen, P.]]
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[[Category: Yaswen P]]
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[[Category: Ca+2 binding protein]]
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[[Category: Ef hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:16:20 2008''
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Current revision

CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS

PDB ID 1ggz

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