1gnh

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{{Seed}}
 
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[[Image:1gnh.png|left|200px]]
 
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<!--
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==HUMAN C-REACTIVE PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1gnh", creates the "Structure Box" on the page.
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<StructureSection load='1gnh' size='340' side='right'caption='[[1gnh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gnh]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1gnh| PDB=1gnh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnh OCA], [https://pdbe.org/1gnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnh RCSB], [https://www.ebi.ac.uk/pdbsum/1gnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CRP_HUMAN CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gnh ConSurf].
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<div style="clear:both"></div>
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===HUMAN C-REACTIVE PROTEIN===
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==See Also==
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*[[C-reactive protein|C-reactive protein]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8599761}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8599761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8599761}}
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==About this Structure==
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1GNH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNH OCA].
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==Reference==
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Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8599761 8599761]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bloomer, A C.]]
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[[Category: Bloomer AC]]
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[[Category: Cheetham, G M.T.]]
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[[Category: Cheetham GMT]]
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[[Category: Greenhough, T J.]]
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[[Category: Greenhough TJ]]
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[[Category: Holden, D.]]
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[[Category: Holden D]]
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[[Category: Myles, D A.]]
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[[Category: Myles DA]]
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[[Category: Pepys, M B.]]
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[[Category: Pepys MB]]
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[[Category: Shrive, A K.]]
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[[Category: Shrive AK]]
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[[Category: Turnell, W G.]]
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[[Category: Turnell WG]]
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[[Category: Volanakis, J E.]]
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[[Category: Volanakis JE]]
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[[Category: Acute-phase protein]]
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[[Category: Acute-phase reactant]]
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[[Category: Pentraxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:33:37 2008''
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Current revision

HUMAN C-REACTIVE PROTEIN

PDB ID 1gnh

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