1god

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{{Seed}}
 
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[[Image:1god.png|left|200px]]
 
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==MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI==
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The line below this paragraph, containing "STRUCTURE_1god", creates the "Structure Box" on the page.
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<StructureSection load='1god' size='340' side='right'caption='[[1god]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1god]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cerrophidion_godmani Cerrophidion godmani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GOD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1god FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1god OCA], [https://pdbe.org/1god PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1god RCSB], [https://www.ebi.ac.uk/pdbsum/1god PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1god ProSAT]</span></td></tr>
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{{STRUCTURE_1god| PDB=1god | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA2H2_CERGO PA2H2_CERGO] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity and shows myotoxicity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/go/1god_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1god ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lys49-Phospholipase A2 (Lys49-PLA2) homologues damage membranes by a Ca2+-independent mechanism which does not involve catalytic activity. With the aim of determining the structural basis for this novel activity, we have solved the crystal structure of myotoxin-II, a Lys49-PLA2 isolated from the venom of Cerrophidion (Bothrops) godmani (godMT-II) at 2.8 A resolution by molecular replacement. The final model has been refined to a final crystallografic residual (Rfactor) of 18.8% (Rfree = 28.2%), with excellent stereochemistry. godMT-II is also monomeric in the crystalline state, and small-angle X-ray scattering results demonstrate that the protein is monomeric in solution under fisicochemical conditions similar to those used in the crystallographic studies.
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===MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI===
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Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.,Arni RK, Fontes MR, Barberato C, Gutierrez JM, Diaz C, Ward RJ Arch Biochem Biophys. 1999 Jun 15;366(2):177-82. PMID:10356281<ref>PMID:10356281</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1god" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10356281}}, adds the Publication Abstract to the page
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10356281 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10356281}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GOD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cerrophidion_godmani Cerrophidion godmani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GOD OCA].
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==Reference==
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Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani., Arni RK, Fontes MR, Barberato C, Gutierrez JM, Diaz C, Ward RJ, Arch Biochem Biophys. 1999 Jun 15;366(2):177-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10356281 10356281]
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[[Category: Cerrophidion godmani]]
[[Category: Cerrophidion godmani]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arni, R K.]]
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[[Category: Arni RK]]
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[[Category: Barberato, C.]]
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[[Category: Barberato C]]
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[[Category: Diaz-Oreiro, C.]]
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[[Category: Diaz-Oreiro C]]
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[[Category: Fontes, M R.M.]]
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[[Category: Fontes MRM]]
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[[Category: Gutierrez, J M.]]
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[[Category: Gutierrez JM]]
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[[Category: Ward, R J.]]
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[[Category: Ward RJ]]
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[[Category: Bothrop]]
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[[Category: Lys49-phospholipase a2]]
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[[Category: Snake venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:36:09 2008''
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Current revision

MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION (BOTHROPS) GODMANI

PDB ID 1god

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