1fyg
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1fyg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fyg" /> '''Solution structure of omega conotoxin SO3 de...) |
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| - | [[Image:1fyg.jpg|left|200px]]<br /><applet load="1fyg" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1fyg" /> | ||
| - | '''Solution structure of omega conotoxin SO3 determined by 1H-NMR'''<br /> | ||
| - | == | + | ==Solution structure of omega conotoxin SO3 determined by 1H-NMR== |
| - | + | <StructureSection load='1fyg' size='340' side='right'caption='[[1fyg]]' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1fyg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYG FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyg OCA], [https://pdbe.org/1fyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyg RCSB], [https://www.ebi.ac.uk/pdbsum/1fyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyg ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| + | [https://www.uniprot.org/uniprot/O16O3_CONST O16O3_CONST] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets Cav2.2/CACNA1B (IC(50)=160 nM) voltage-gated calcium channels (PubMed:26344359). When tested in mammals, this toxin displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects (tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion) compared with identical dosages of MVIIA injected intrathecally.<ref>PMID:15880145</ref> <ref>PMID:26344359</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conus striatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yan Y]] | ||
| + | [[Category: Zhang R]] | ||
Current revision
Solution structure of omega conotoxin SO3 determined by 1H-NMR
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