1gqu

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[[Image:1gqu.png|left|200px]]
 
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==Crystal structure of an alternating A-T oligonucleotide fragment with Hoogsteen base pairing==
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The line below this paragraph, containing "STRUCTURE_1gqu", creates the "Structure Box" on the page.
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<StructureSection load='1gqu' size='340' side='right'caption='[[1gqu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gqu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr>
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{{STRUCTURE_1gqu| PDB=1gqu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gqu OCA], [https://pdbe.org/1gqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gqu RCSB], [https://www.ebi.ac.uk/pdbsum/1gqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gqu ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report here an alternative double-helical structure of the DNA molecule. It has been found in the d(ATA(Br)UAT) and d(ATATAT) sequences by single-crystal x-ray crystallography. This sequence is found not only in TATA boxes, but also in other regulatory regions of DNA. Bases of the two antiparallel strands form Hoogsteen pairs, with adenines in the syn conformation. The structure is related neither to those found in triple helices nor to parallel DNA duplexes. Its conformational parameters are very similar to those of duplex DNA in the B form. Both forms may coexist under physiological conditions, although the Hoogsteen pairing greatly influences the recognition sites on DNA. Our results demonstrate that an alternative to the classical B-DNA double helix is possible.
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===CRYSTAL STRUCTURE OF AN ALTERNATING A-T OLIGONUCLEOTIDE FRAGMENT WITH HOOGSTEEN BASE PAIRING===
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Crystal structure of an antiparallel DNA fragment with Hoogsteen base pairing.,Abrescia NG, Thompson A, Huynh-Dinh T, Subirana JA Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2806-11. PMID:11880632<ref>PMID:11880632</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_11880632}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gqu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11880632 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11880632}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQU OCA].
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[[Category: Abrescia NGA]]
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[[Category: Huynh-Dinh T]]
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==Reference==
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[[Category: Subirana JA]]
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Crystal structure of an antiparallel DNA fragment with Hoogsteen base pairing., Abrescia NG, Thompson A, Huynh-Dinh T, Subirana JA, Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2806-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11880632 11880632]
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[[Category: Thompson A]]
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[[Category: Abrescia, N G.A.]]
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[[Category: Huynh-Dinh, T.]]
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[[Category: Subirana, J A.]]
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[[Category: Thompson, A.]]
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[[Category: Hoogsteen base pairing]]
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[[Category: New dna structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:55:21 2008''
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Current revision

Crystal structure of an alternating A-T oligonucleotide fragment with Hoogsteen base pairing

PDB ID 1gqu

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