1grw

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{{Seed}}
 
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[[Image:1grw.png|left|200px]]
 
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==C. elegans major sperm protein==
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The line below this paragraph, containing "STRUCTURE_1grw", creates the "Structure Box" on the page.
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<StructureSection load='1grw' size='340' side='right'caption='[[1grw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1grw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GRW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1grw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1grw OCA], [https://pdbe.org/1grw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1grw RCSB], [https://www.ebi.ac.uk/pdbsum/1grw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1grw ProSAT]</span></td></tr>
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{{STRUCTURE_1grw| PDB=1grw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSP19_CAEEL MSP19_CAEEL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/1grw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1grw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The amoeboid locomotion of nematode sperm is mediated by the assembly dynamics of the major sperm protein (MSP). MSP forms fibrous networks based on a hierarchy of macromolecular assemblies: helical subfilaments are built from MSP dimers; filaments are formed from two subfilaments coiling round one another; and filaments themselves supercoil to produce bundles. To provide a structural context for understanding the role of these macromolecular assemblies in cell locomotion, we have determined the 2.6 A resolution structure of crystals of Caenorhabditis elegans MSP that are constructed from helices of MSP chains that are analogous to the subfilaments from which filaments are constructed. Comparison with the crystal structures of dimers and helical assemblies of Ascaris suum MSP has identified five conserved interaction interfaces that suggest how subfilaments interact in filaments and how filaments can form bundles. The interfaces frequently involve the loop containing residues 78-85, which is divergent between MSP homologues, and the loop containing residues 98-103, which is highly conserved.
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===C. ELEGANS MAJOR SPERM PROTEIN===
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2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans.,Baker AM, Roberts TM, Stewart M J Mol Biol. 2002 May 31;319(2):491-9. PMID:12051923<ref>PMID:12051923</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12051923}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1grw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12051923 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12051923}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GRW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GRW OCA].
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==Reference==
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2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans., Baker AM, Roberts TM, Stewart M, J Mol Biol. 2002 May 31;319(2):491-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12051923 12051923]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, A M.E.]]
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[[Category: Baker AME]]
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[[Category: Roberts, T M.]]
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[[Category: Roberts TM]]
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[[Category: Stewart, M.]]
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[[Category: Stewart M]]
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[[Category: Cell motility]]
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[[Category: Cytoskeleton]]
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[[Category: Cytosketal protein]]
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[[Category: Sperm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:58:27 2008''
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Current revision

C. elegans major sperm protein

PDB ID 1grw

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