1gtq

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{{Seed}}
 
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[[Image:1gtq.png|left|200px]]
 
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==6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE==
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The line below this paragraph, containing "STRUCTURE_1gtq", creates the "Structure Box" on the page.
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<StructureSection load='1gtq' size='340' side='right'caption='[[1gtq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gtq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. The August 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Tetrahydrobiopterin Biosynthesis'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_8 10.2210/rcsb_pdb/mom_2015_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GTQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1gtq| PDB=1gtq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtq OCA], [https://pdbe.org/1gtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gtq RCSB], [https://www.ebi.ac.uk/pdbsum/1gtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gtq ProSAT]</span></td></tr>
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</table>
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===6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE===
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== Disease ==
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[https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Note=Deficiency leads to phenylketonuria.
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== Function ==
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[https://www.uniprot.org/uniprot/PTPS_RAT PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
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The line below this paragraph, {{ABSTRACT_PUBMED_8137809}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 8137809 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_8137809}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gtq_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1GTQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTQ OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gtq ConSurf].
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Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis., Nar H, Huber R, Heizmann CW, Thony B, Burgisser D, EMBO J. 1994 Mar 15;13(6):1255-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8137809 8137809]
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<div style="clear:both"></div>
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[[Category: 6-pyruvoyltetrahydropterin synthase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
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[[Category: Single protein]]
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[[Category: Tetrahydrobiopterin Biosynthesis]]
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[[Category: Buergisser, D.]]
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[[Category: Buergisser D]]
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[[Category: Heizmann, C W.]]
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[[Category: Heizmann CW]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Nar, H.]]
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[[Category: Nar H]]
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[[Category: Thoeny, B.]]
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[[Category: Thoeny B]]
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[[Category: Phosphate elimination]]
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[[Category: Pterine synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:04:00 2008''
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Current revision

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

PDB ID 1gtq

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