1gxr

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{{Seed}}
 
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[[Image:1gxr.png|left|200px]]
 
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==WD40 Region of Human Groucho/TLE1==
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The line below this paragraph, containing "STRUCTURE_1gxr", creates the "Structure Box" on the page.
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<StructureSection load='1gxr' size='340' side='right'caption='[[1gxr]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1gxr| PDB=1gxr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxr OCA], [https://pdbe.org/1gxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxr RCSB], [https://www.ebi.ac.uk/pdbsum/1gxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Groucho (Gro)/TLE proteins are transcriptional corepressors that lack inherent DNA binding but interact with DNA-bound transcription factors and histones, and recruit histone deacetylases. Groucho-mediated repression is essential in embryonic development and involved in regulation of Wnt signaling in adult tissue. We have determined the 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions. The structure confirms the relationship to the yeast Tup1 corepressor, but reveals important structural differences specific to the metazoan system. Analysis of missense mutations in the C. elegans Groucho homolog UNC-37 identifies sites of interaction with repression effectors, and suggests an induced fit binding site for eh1 domains of Engrailed-type transcription factors.
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===WD40 REGION OF HUMAN GROUCHO/TLE1===
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Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.,Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH Structure. 2002 Jun;10(6):751-61. PMID:12057191<ref>PMID:12057191</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12057191}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gxr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12057191 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12057191}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1GXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXR OCA].
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==Reference==
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Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor., Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH, Structure. 2002 Jun;10(6):751-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12057191 12057191]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Pearl, L H.]]
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[[Category: Pearl LH]]
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[[Category: Pickles, L M.]]
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[[Category: Pickles LM]]
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[[Category: Roe, S M.]]
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[[Category: Roe SM]]
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[[Category: Transcription repressor]]
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[[Category: Wd repeat]]
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[[Category: Wd40]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:17:16 2008''
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Current revision

WD40 Region of Human Groucho/TLE1

PDB ID 1gxr

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