1h1n

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{{Seed}}
 
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[[Image:1h1n.png|left|200px]]
 
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==Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus==
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The line below this paragraph, containing "STRUCTURE_1h1n", creates the "Structure Box" on the page.
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<StructureSection load='1h1n' size='340' side='right'caption='[[1h1n]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoascus_aurantiacus Thermoascus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H1N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1n OCA], [https://pdbe.org/1h1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h1n RCSB], [https://www.ebi.ac.uk/pdbsum/1h1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h1n ProSAT]</span></td></tr>
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{{STRUCTURE_1h1n| PDB=1h1n | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8TG26_THEAU Q8TG26_THEAU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/1h1n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h1n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the major endoglucanase from the thermophilic fungus Thermoascus aurantiacus was determined by single isomorphous replacement at 1.12A resolution. The full sequence supports the classification of the protein in a subgroup of glycoside hydrolase family 5 for which no structural data are available yet. The active site shows eight critical residues, strictly conserved within family 5. In addition, aromatic residues that line the substrate-binding cleft and that are possibly involved in substrate-binding are identified. A number of residues seem to be conserved among members of the subtype, including a disulphide bridge between Cys212 and Cys249.
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===ATOMIC RESOLUTION STRUCTURE OF THE MAJOR ENDOGLUCANASE FROM THERMOASCUS AURANTIACUS===
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Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus.,Van Petegem F, Vandenberghe I, Bhat MK, Van Beeumen J Biochem Biophys Res Commun. 2002 Aug 9;296(1):161-6. PMID:12147244<ref>PMID:12147244</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1h1n" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12147244}}, adds the Publication Abstract to the page
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12147244 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12147244}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1H1N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoascus_aurantiacus Thermoascus aurantiacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1N OCA].
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==Reference==
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Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus., Van Petegem F, Vandenberghe I, Bhat MK, Van Beeumen J, Biochem Biophys Res Commun. 2002 Aug 9;296(1):161-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12147244 12147244]
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[[Category: Cellulase]]
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[[Category: Single protein]]
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[[Category: Thermoascus aurantiacus]]
[[Category: Thermoascus aurantiacus]]
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[[Category: Beeumen, J Van.]]
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[[Category: Bhat MK]]
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[[Category: Bhat, M K.]]
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[[Category: Van Beeumen J]]
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[[Category: Petegem, F Van.]]
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[[Category: Van Petegem F]]
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[[Category: Vandenberghe, I.]]
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[[Category: Vandenberghe I]]
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[[Category: Endoglucanase]]
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[[Category: Family 5]]
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[[Category: Glycosyl hydrolase]]
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[[Category: Subtype]]
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[[Category: Thermophile]]
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[[Category: Thermophilic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:28:13 2008''
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Current revision

Atomic resolution structure of the major endoglucanase from Thermoascus aurantiacus

PDB ID 1h1n

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