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1h1r

From Proteopedia

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{{Seed}}
 
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[[Image:1h1r.png|left|200px]]
 
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==Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086==
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The line below this paragraph, containing "STRUCTURE_1h1r", creates the "Structure Box" on the page.
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<StructureSection load='1h1r' size='340' side='right'caption='[[1h1r]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h1r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H1R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6CP:6-CYCLOHEXYLMETHOXY-2-(3-CHLOROANILINO)+PURINE'>6CP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_1h1r| PDB=1h1r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1r OCA], [https://pdbe.org/1h1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h1r RCSB], [https://www.ebi.ac.uk/pdbsum/1h1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h1r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/1h1r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h1r ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU6086===
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==See Also==
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*[[Cyclin 3D structures|Cyclin 3D structures]]
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_12244298}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 12244298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12244298}}
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==About this Structure==
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1H1R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1R OCA].
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==Reference==
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Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor., Davies TG, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury P, Johnson LN, Mesguiche V, Newell DR, Noble ME, Tucker JA, Wang L, Whitfield HJ, Nat Struct Biol. 2002 Oct;9(10):745-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12244298 12244298]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Davies, T G.]]
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[[Category: Davies TG]]
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[[Category: Endicott, J A.]]
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[[Category: Endicott JA]]
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[[Category: Johnson, L N.]]
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[[Category: Johnson LN]]
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[[Category: Noble, M E.M.]]
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[[Category: Noble MEM]]
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[[Category: Atp-binding]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Kinase]]
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[[Category: Mitosis]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:28:34 2008''
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Current revision

Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086

PDB ID 1h1r

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