1h30

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{{Seed}}
 
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[[Image:1h30.png|left|200px]]
 
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==C-terminal LG domain pair of human Gas6==
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The line below this paragraph, containing "STRUCTURE_1h30", creates the "Structure Box" on the page.
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<StructureSection load='1h30' size='340' side='right'caption='[[1h30]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H30 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1h30| PDB=1h30 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h30 OCA], [https://pdbe.org/1h30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h30 RCSB], [https://www.ebi.ac.uk/pdbsum/1h30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h30 ProSAT]</span></td></tr>
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</table>
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===C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6===
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== Function ==
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[https://www.uniprot.org/uniprot/GAS6_HUMAN GAS6_HUMAN] Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.<ref>PMID:12364394</ref> <ref>PMID:18840707</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12218057 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h30_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12218057}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1H30 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h30 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12218057 12218057]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cheburkin, Y.]]
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[[Category: Cheburkin Y]]
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[[Category: Gohring, W.]]
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[[Category: Gohring W]]
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[[Category: Hohenester, E.]]
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[[Category: Hohenester E]]
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[[Category: Knyazev, P G.]]
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[[Category: Knyazev PG]]
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[[Category: Sasaki, T.]]
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[[Category: Sasaki T]]
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[[Category: Timpl, R.]]
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[[Category: Timpl R]]
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[[Category: Tisi, D.]]
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[[Category: Tisi D]]
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[[Category: Ullrich, A.]]
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[[Category: Ullrich A]]
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[[Category: Axl/sky/mer ligand]]
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[[Category: Calcium-binding]]
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[[Category: Egf-like domain]]
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[[Category: Laminin g-like domain]]
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[[Category: Vitamin k-dependent protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:32:24 2008''
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Current revision

C-terminal LG domain pair of human Gas6

PDB ID 1h30

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