1h8c

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{{Seed}}
 
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[[Image:1h8c.png|left|200px]]
 
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==UBX domain from human faf1==
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The line below this paragraph, containing "STRUCTURE_1h8c", creates the "Structure Box" on the page.
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<StructureSection load='1h8c' size='340' side='right'caption='[[1h8c]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8c OCA], [https://pdbe.org/1h8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8c RCSB], [https://www.ebi.ac.uk/pdbsum/1h8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8c ProSAT]</span></td></tr>
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{{STRUCTURE_1h8c| PDB=1h8c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAF1_HUMAN FAF1_HUMAN] Potentiates but cannot initiate FAS-induced apoptosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h8c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The UBX domain is an 80 amino acid residue module that is present typically at the carboxyl terminus of a variety of eukaryotic proteins. In an effort to elucidate the function of UBX domains, we solved the three-dimensional structure of the UBX domain of human Fas-associated factor-1 (FAF1) by NMR spectroscopy. The structure has a beta-Grasp fold characterised by a beta-beta-alpha-beta-beta-alpha-beta secondary-structure organisation. The five beta strands are arranged into a mixed sheet in the order 21534. The longer first helix packs across the first three strands of the sheet, and a second shorter 3(10) helix is located in an extended loop connecting strands 4 and 5. In the absence of significant sequence similarity, the UBX domain can be superimposed with ubiquitin with an r.m.s.d. of 1.9 A, suggesting that the two structures share the same superfold, and an evolutionary relationship. However, the absence of a carboxyl-terminal extension containing a double glycine motif and of suitably positioned lysine side-chains makes it highly unlikely that UBX domains are either conjugated to other proteins or part of mixed UBX-ubiquitin chains. Database searches revealed that most UBX domain-containing proteins belong to one of four evolutionarily conserved families represented by the human FAF1, p47, Y33K, and Rep8 proteins. A role of the UBX domain in ubiquitin-related processes is suggested.
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===UBX DOMAIN FROM HUMAN FAF1===
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The UBX domain: a widespread ubiquitin-like module.,Buchberger A, Howard MJ, Proctor M, Bycroft M J Mol Biol. 2001 Mar 16;307(1):17-24. PMID:11243799<ref>PMID:11243799</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11243799}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1h8c" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11243799 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11243799}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1H8C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8C OCA].
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==Reference==
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The UBX domain: a widespread ubiquitin-like module., Buchberger A, Howard MJ, Proctor M, Bycroft M, J Mol Biol. 2001 Mar 16;307(1):17-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11243799 11243799]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bycroft, M.]]
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[[Category: Bycroft MM]]
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[[Category: Faf1 ubx domain ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:47:45 2008''
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Current revision

UBX domain from human faf1

PDB ID 1h8c

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OCA

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