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1ha1

From Proteopedia

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{{Seed}}
 
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[[Image:1ha1.png|left|200px]]
 
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==HNRNP A1 (RBD1,2) FROM HOMO SAPIENS==
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The line below this paragraph, containing "STRUCTURE_1ha1", creates the "Structure Box" on the page.
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<StructureSection load='1ha1' size='340' side='right'caption='[[1ha1]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ha1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HA1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ha1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ha1 OCA], [https://pdbe.org/1ha1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ha1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ha1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ha1 ProSAT]</span></td></tr>
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{{STRUCTURE_1ha1| PDB=1ha1 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/1ha1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ha1 ConSurf].
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<div style="clear:both"></div>
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===HNRNP A1 (RBD1,2) FROM HOMO SAPIENS===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_9164463}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 9164463 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_9164463}}
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==About this Structure==
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1HA1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA1 OCA].
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==Reference==
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Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75 A resolution., Shamoo Y, Krueger U, Rice LM, Williams KR, Steitz TA, Nat Struct Biol. 1997 Mar;4(3):215-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9164463 9164463]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Krueger, U.]]
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[[Category: Krueger U]]
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[[Category: Rice, L.]]
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[[Category: Rice L]]
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[[Category: Shamoo, Y.]]
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[[Category: Shamoo Y]]
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[[Category: Steitz, T A.]]
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[[Category: Steitz TA]]
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[[Category: Williams, K R.]]
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[[Category: Williams KR]]
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[[Category: Hnrnp]]
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[[Category: Nuclear protein]]
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[[Category: Rbd]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna binding]]
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[[Category: Rnp]]
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[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:52:45 2008''
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Current revision

HNRNP A1 (RBD1,2) FROM HOMO SAPIENS

PDB ID 1ha1

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