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1hi4

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{{Seed}}
 
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[[Image:1hi4.png|left|200px]]
 
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==Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex==
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The line below this paragraph, containing "STRUCTURE_1hi4", creates the "Structure Box" on the page.
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<StructureSection load='1hi4' size='340' side='right'caption='[[1hi4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HI4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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{{STRUCTURE_1hi4| PDB=1hi4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hi4 OCA], [https://pdbe.org/1hi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1hi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hi4 ProSAT]</span></td></tr>
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</table>
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===EOSINOPHIL-DERIVED NEUROTOXIN (EDN)-ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/RNAS2_HUMAN RNAS2_HUMAN] This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.<ref>PMID:3458170</ref> <ref>PMID:12578357</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11154698}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11154698 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hi4_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11154698}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HI4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hi4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors., Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR, J Biol Chem. 2001 May 4;276(18):15009-17. Epub 2001 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11154698 11154698]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Acharya KR]]
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[[Category: Acharya, K R.]]
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[[Category: Boix E]]
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[[Category: Boix, E.]]
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[[Category: Leonidas DD]]
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[[Category: Leonidas, D D.]]
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[[Category: Minson K]]
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[[Category: Minson, K.]]
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[[Category: Prill R]]
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[[Category: Prill, R.]]
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[[Category: Suzuki M]]
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[[Category: Suzuki, M.]]
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[[Category: Swaminathan GJ]]
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[[Category: Swaminathan, G J.]]
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[[Category: Turton R]]
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[[Category: Turton, R.]]
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[[Category: Youle RJ]]
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[[Category: Youle, R J.]]
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[[Category: Ribonuclease]]
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[[Category: Rnase us]]
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[[Category: Rnase-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:12:47 2008''
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Current revision

Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex

PDB ID 1hi4

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