1hi7

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[[Image:1hi7.png|left|200px]]
 
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==NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1hi7", creates the "Structure Box" on the page.
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<StructureSection load='1hi7' size='340' side='right'caption='[[1hi7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hi7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HI7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hi7 OCA], [https://pdbe.org/1hi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hi7 RCSB], [https://www.ebi.ac.uk/pdbsum/1hi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hi7 ProSAT]</span></td></tr>
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{{STRUCTURE_1hi7| PDB=1hi7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TFF1_HUMAN TFF1_HUMAN] Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.<ref>PMID:16308573</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hi7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hi7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The trefoil factor family protein, TFF1, forms a homodimer, via a disulphide linkage, that has greater activity in wound healing assays than the monomer. Having previously determined a high-resolution solution structure of a monomeric analogue of TFF1, we now investigate the structure of the homodimer formed by the native sequence. The two putative receptor/ligand recognition domains are found to be well separated, at opposite ends of a flexible linker. This contrasts sharply with the known fixed and compact arrangement of the two trefoil domains of the closely related TFF2, and has significant implications for the mechanism of action and functional specificity of the TFF of proteins.
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===NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES===
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The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1.,Williams MA, Westley BR, May FE, Feeney J FEBS Lett. 2001 Mar 30;493(2-3):70-4. PMID:11286998<ref>PMID:11286998</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11286998}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1hi7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11286998 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11286998}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1HI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI7 OCA].
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==Reference==
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The solution structure of the disulphide-linked homodimer of the human trefoil protein TFF1., Williams MA, Westley BR, May FE, Feeney J, FEBS Lett. 2001 Mar 30;493(2-3):70-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11286998 11286998]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Feeney, J.]]
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[[Category: Feeney J]]
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[[Category: Williams, M A.]]
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[[Category: Williams MA]]
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[[Category: Cell motility]]
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[[Category: Growth factor]]
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[[Category: Signal]]
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[[Category: Trefoil domain]]
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[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:13:11 2008''
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Current revision

NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES

PDB ID 1hi7

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