1hkl

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{{Seed}}
 
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[[Image:1hkl.png|left|200px]]
 
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==FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY==
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The line below this paragraph, containing "STRUCTURE_1hkl", creates the "Structure Box" on the page.
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<StructureSection load='1hkl' size='340' side='right'caption='[[1hkl]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hkl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkl OCA], [https://pdbe.org/1hkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkl RCSB], [https://www.ebi.ac.uk/pdbsum/1hkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkl ProSAT]</span></td></tr>
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{{STRUCTURE_1hkl| PDB=1hkl | SCENE= }}
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the esterase catalytic antibody 48G7 has been determined in the presence of hapten at 2.0 A resolution and in the absence of hapten at 2.7 A resolution. The root-mean-square difference between the two structures is 0.6 A for the variable domain and 0.7 A for the constant domain. Comparison of the active site shows that no significant changes occur upon hapten binding as main-chain and side-chain displacements are negligible. Complex formation occurs as hapten fits into a pre-formed pocket about 10 A deep. Although 151 water molecules were modeled into the 48G7-hapten structure, none are bound in the active site. Comparison of the 48G7 structures with those of other published ester hydrolysis antibodies illustrates an emerging theme used by esterolytic antibodies in binding their (nitro-)phenyl haptens and in hydrolysing their cognate esters and carbonates: hapten is bound with the aryl end buried deep in the binding pocket, and the phosphonate moiety is responsible for the majority of the binding energy to the antibody-hapten interaction.
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===FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY===
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Crystal structures of the free and liganded form of an esterolytic catalytic antibody.,Wedemayer GJ, Wang LH, Patten PA, Schultz PG, Stevens RC J Mol Biol. 1997 May 2;268(2):390-400. PMID:9159478<ref>PMID:9159478</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1hkl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_9159478}}, adds the Publication Abstract to the page
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9159478 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9159478}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1HKL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKL OCA].
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==Reference==
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Crystal structures of the free and liganded form of an esterolytic catalytic antibody., Wedemayer GJ, Wang LH, Patten PA, Schultz PG, Stevens RC, J Mol Biol. 1997 May 2;268(2):390-400. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9159478 9159478]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Patten, P A.]]
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[[Category: Patten PA]]
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[[Category: Schultz, P G.]]
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[[Category: Schultz PG]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens RC]]
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[[Category: Wang, L H.]]
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[[Category: Wang LH]]
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[[Category: Wedemayer, G J.]]
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[[Category: Wedemayer GJ]]
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[[Category: Catalytic antibody]]
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[[Category: Ester hydrolysis]]
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[[Category: Esterolytic]]
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[[Category: Fab]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:19:13 2008''
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Current revision

FREE AND LIGANDED FORM OF AN ESTEROLYTIC CATALYTIC ANTIBODY

PDB ID 1hkl

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