1hkt

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{{Seed}}
 
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[[Image:1hkt.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR==
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The line below this paragraph, containing "STRUCTURE_1hkt", creates the "Structure Box" on the page.
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<StructureSection load='1hkt' size='340' side='right'caption='[[1hkt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkt OCA], [https://pdbe.org/1hkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkt RCSB], [https://www.ebi.ac.uk/pdbsum/1hkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkt ProSAT]</span></td></tr>
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{{STRUCTURE_1hkt| PDB=1hkt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSF_DROME HSF_DROME] DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the DNA-binding domain of the Drosophila heat shock transcription factor, as determined by multidimensional multinuclear NMR, resembles that of the helix-turn-helix class of DNA-binding proteins. The domain comprises a four-stranded antiparallel beta-sheet, packed against a three-helix bundle. The second helix is significantly distorted and is separated from the third helix by an extended turn which is subject to conformational averaging on an intermediate time scale. Helix 3 forms a classical amphipathic helix with polar and charged residues exposed to the solvent. Upon titration with DNA, resonance shifts in the backbone and Asn and Gln side-chain amides indicate that helix 3 acts as the recognition helix of the heat shock transcription factor.
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===SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR===
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Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.,Vuister GW, Kim SJ, Orosz A, Marquardt J, Wu C, Bax A Nat Struct Biol. 1994 Sep;1(9):605-14. PMID:7634100<ref>PMID:7634100</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1hkt" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_7634100}}, adds the Publication Abstract to the page
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*[[Heat shock factor|Heat shock factor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7634100 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7634100}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1HKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKT OCA].
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==Reference==
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Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor., Vuister GW, Kim SJ, Orosz A, Marquardt J, Wu C, Bax A, Nat Struct Biol. 1994 Sep;1(9):605-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634100 7634100]
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bax, A.]]
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[[Category: Bax A]]
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[[Category: Kim, S J.]]
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[[Category: Kim S-J]]
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[[Category: Marquardt, J L.]]
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[[Category: Marquardt JL]]
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[[Category: Orosz, A.]]
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[[Category: Orosz A]]
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[[Category: Vuister, G W.]]
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[[Category: Vuister GW]]
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[[Category: Wu, C.]]
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[[Category: Wu C]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:19:39 2008''
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Current revision

SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR

PDB ID 1hkt

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