1g6i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1g6i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g6i, resolution 1.59&Aring;" /> '''CRYSTAL STRUCTURE OF...)
Current revision (11:19, 27 March 2024) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1g6i.gif|left|200px]]<br /><applet load="1g6i" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1g6i, resolution 1.59&Aring;" />
 
-
'''CRYSTAL STRUCTURE OF THE YEAST ALPHA-1,2-MANNOSIDASE WITH BOUND 1-DEOXYMANNOJIRIMYCIN AT 1.59 A RESOLUTION'''<br />
 
-
==About this Structure==
+
==Crystal structure of the yeast alpha-1,2-mannosidase with bound 1-deoxymannojirimycin at 1.59 A resolution==
-
1G6I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with NAG, CA and DMJ as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1G6I OCA].
+
<StructureSection load='1g6i' size='340' side='right'caption='[[1g6i]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
-
[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
+
== Structural highlights ==
-
[[Category: Saccharomyces cerevisiae]]
+
<table><tr><td colspan='2'>[[1g6i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G6I FirstGlance]. <br>
-
[[Category: Single protein]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-
[[Category: Herscovics, A.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMJ:1-DEOXYMANNOJIRIMYCIN'>DMJ</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
-
[[Category: Howell, P.A]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6i OCA], [https://pdbe.org/1g6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g6i RCSB], [https://www.ebi.ac.uk/pdbsum/1g6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g6i ProSAT]</span></td></tr>
-
[[Category: Lipari, F.]]
+
</table>
-
[[Category: Romera, P.A.]]
+
== Function ==
-
[[Category: Sleno, B.]]
+
[https://www.uniprot.org/uniprot/MNS1_YEAST MNS1_YEAST] Involved in glycoprotein quality control as it is important for the targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations it further trims the carbohydrates to Man(5)GlcNAc(2).<ref>PMID:12090241</ref>
-
[[Category: Vallee, F.]]
+
== Evolutionary Conservation ==
-
[[Category: Yip, P.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: CA]]
+
Check<jmol>
-
[[Category: DMJ]]
+
<jmolCheckbox>
-
[[Category: NAG]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/1g6i_consurf.spt"</scriptWhenChecked>
-
[[Category: alpha-alpha7 barrel]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g6i ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:45:19 2007''
+
==See Also==
 +
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Saccharomyces cerevisiae]]
 +
[[Category: Herscovics A]]
 +
[[Category: Howell PA]]
 +
[[Category: Lipari F]]
 +
[[Category: Romera PA]]
 +
[[Category: Sleno B]]
 +
[[Category: Vallee F]]
 +
[[Category: Yip P]]

Current revision

Crystal structure of the yeast alpha-1,2-mannosidase with bound 1-deoxymannojirimycin at 1.59 A resolution

PDB ID 1g6i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g6i"
Personal tools