1hlo

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{{Seed}}
 
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[[Image:1hlo.png|left|200px]]
 
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==THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL==
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The line below this paragraph, containing "STRUCTURE_1hlo", creates the "Structure Box" on the page.
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<StructureSection load='1hlo' size='340' side='right'caption='[[1hlo]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hlo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlo OCA], [https://pdbe.org/1hlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hlo RCSB], [https://www.ebi.ac.uk/pdbsum/1hlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlo ProSAT]</span></td></tr>
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{{STRUCTURE_1hlo| PDB=1hlo | SCENE= }}
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</table>
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== Function ==
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===THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL===
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[https://www.uniprot.org/uniprot/MAX_HUMAN MAX_HUMAN] Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9115440 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hlo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9115440}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hlo ConSurf].
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1HLO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLO OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control., Brownlie P, Ceska T, Lamers M, Romier C, Stier G, Teo H, Suck D, Structure. 1997 Apr 15;5(4):509-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9115440 9115440]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brownlie, P.]]
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[[Category: Brownlie P]]
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[[Category: Ceska, T A.]]
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[[Category: Ceska TA]]
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[[Category: Lamers, M.]]
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[[Category: Lamers M]]
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[[Category: Romier, C.]]
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[[Category: Romier C]]
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[[Category: Suck, D.]]
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[[Category: Suck D]]
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[[Category: Theo, H.]]
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[[Category: Theo H]]
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[[Category: Dna binding]]
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[[Category: Transcriptional regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:21:59 2008''
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Current revision

THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL

PDB ID 1hlo

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