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1hmk

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{{Seed}}
 
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[[Image:1hmk.png|left|200px]]
 
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<!--
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==RECOMBINANT GOAT ALPHA-LACTALBUMIN==
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The line below this paragraph, containing "STRUCTURE_1hmk", creates the "Structure Box" on the page.
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<StructureSection load='1hmk' size='340' side='right'caption='[[1hmk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hmk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1hmk| PDB=1hmk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmk OCA], [https://pdbe.org/1hmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmk RCSB], [https://www.ebi.ac.uk/pdbsum/1hmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LALBA_CAPHI LALBA_CAPHI] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/1hmk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hmk ConSurf].
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<div style="clear:both"></div>
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===RECOMBINANT GOAT ALPHA-LACTALBUMIN===
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==See Also==
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*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9887272}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9887272 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9887272}}
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==About this Structure==
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1HMK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMK OCA].
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==Reference==
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Effect of the extra n-terminal methionine residue on the stability and folding of recombinant alpha-lactalbumin expressed in Escherichia coli., Chaudhuri TK, Horii K, Yoda T, Arai M, Nagata S, Terada TP, Uchiyama H, Ikura T, Tsumoto K, Kataoka H, Matsushima M, Kuwajima K, Kumagai I, J Mol Biol. 1999 Jan 22;285(3):1179-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9887272 9887272]
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[[Category: Capra hircus]]
[[Category: Capra hircus]]
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[[Category: Lactose synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Horii K]]
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[[Category: Horii, K.]]
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[[Category: Kumagai I]]
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[[Category: Kumagai, I.]]
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[[Category: Matsushima M]]
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[[Category: Matsushima, M.]]
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[[Category: Tsumoto K]]
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[[Category: Tsumoto, K.]]
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[[Category: Calcium binding metalloprotein]]
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[[Category: Glycoprotein]]
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[[Category: Lactose synthase component]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:24:12 2008''
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Current revision

RECOMBINANT GOAT ALPHA-LACTALBUMIN

PDB ID 1hmk

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