1hmj

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{{Seed}}
 
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[[Image:1hmj.png|left|200px]]
 
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==SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H==
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The line below this paragraph, containing "STRUCTURE_1hmj", creates the "Structure Box" on the page.
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<StructureSection load='1hmj' size='340' side='right'caption='[[1hmj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmj OCA], [https://pdbe.org/1hmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmj RCSB], [https://www.ebi.ac.uk/pdbsum/1hmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmj ProSAT]</span></td></tr>
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{{STRUCTURE_1hmj| PDB=1hmj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPO5_METJA RPO5_METJA] DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/1hmj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hmj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The archaeal H and eukaryotic RPB5 RNA polymerase subunits are highly homologous and are likely to play a fundamental role in transcription that extends from archaea to humans. We report the structure of subunit H, in solution, from the archaeon Methanococcus jannaschii using multidimensional nuclear magnetic resonance. The structure reveals a novel fold containing a four-stranded mixed beta sheet that is flanked on one side by three short helices. The dominant feature is beta-ribbon motif, which presents a hydrophobic, basic surface, and defines a general RNA polymerase architectural scaffold.
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===SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H===
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RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes.,Thiru A, Hodach M, Eloranta JJ, Kostourou V, Weinzierl RO, Matthews S J Mol Biol. 1999 Apr 9;287(4):753-60. PMID:10191143<ref>PMID:10191143</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10191143}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1hmj" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10191143 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10191143}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1HMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMJ OCA].
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==Reference==
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RNA polymerase subunit H features a beta-ribbon motif within a novel fold that is present in archaea and eukaryotes., Thiru A, Hodach M, Eloranta JJ, Kostourou V, Weinzierl RO, Matthews S, J Mol Biol. 1999 Apr 9;287(4):753-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10191143 10191143]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Eloranta J]]
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[[Category: Eloranta, J.]]
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[[Category: Hodach M]]
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[[Category: Hodach, M.]]
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[[Category: Kostourou V]]
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[[Category: Kostourou, V.]]
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[[Category: Thiru A]]
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[[Category: Thiru, A.]]
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[[Category: Weinzierl R]]
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[[Category: Weinzierl, R.]]
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[[Category: Archaea]]
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[[Category: Rna polymerase]]
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[[Category: Rpb5]]
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[[Category: Subunit h]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:24:12 2008''
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Current revision

SOLUTION STRUCTURE OF RNA POLYMERASE SUBUNIT H

PDB ID 1hmj

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OCA

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