1hn0

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{{Seed}}
 
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[[Image:1hn0.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF CHONDROITIN ABC LYASE I FROM PROTEUS VULGARIS AT 1.9 ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_1hn0", creates the "Structure Box" on the page.
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<StructureSection load='1hn0' size='340' side='right'caption='[[1hn0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_vulgaris Proteus vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HN0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_1hn0| PDB=1hn0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hn0 OCA], [https://pdbe.org/1hn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1hn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hn0 ProSAT]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF CHONDROITIN ABC LYASE I FROM PROTEUS VULGARIS AT 1.9 ANGSTROMS RESOLUTION===
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== Function ==
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[https://www.uniprot.org/uniprot/CABC1_PROVU CABC1_PROVU] Endolytic, broad-specificity glycosaminoglycan lyase, which degrades the polysaccharides chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate and to a lesser extent hyaluronan, by beta-elimination of 1,4-hexosaminidic bond to unsaturated tetrasaccharides and disaccharides. Is not active against keratan sulfate, heparan sulfate, and heparin. Is able to promote functional recovery in the injured central nervous system (CNS), via its role in the disruption of the normal organization of the extracellular matrix (ECM).<ref>PMID:15691229</ref> <ref>PMID:17572406</ref> <ref>PMID:9083041</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12706721}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12706721 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hn0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12706721}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HN0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Proteus_vulgaris Proteus vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HN0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hn0 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of Proteus vulgaris chondroitin sulfate ABC lyase I at 1.9A resolution., Huang W, Lunin VV, Li Y, Suzuki S, Sugiura N, Miyazono H, Cygler M, J Mol Biol. 2003 May 2;328(3):623-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12706721 12706721]
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<references/>
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[[Category: Chondroitin-sulfate-ABC endolyase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Proteus vulgaris]]
[[Category: Proteus vulgaris]]
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[[Category: Single protein]]
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[[Category: Cygler M]]
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[[Category: Cygler, M.]]
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[[Category: Huang W]]
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[[Category: Huang, W.]]
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[[Category: Chondroitinase abc i]]
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[[Category: Chonroitin digestion]]
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[[Category: Mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:25:00 2008''
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Current revision

CRYSTAL STRUCTURE OF CHONDROITIN ABC LYASE I FROM PROTEUS VULGARIS AT 1.9 ANGSTROMS RESOLUTION

PDB ID 1hn0

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