1hnn

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{{Seed}}
 
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[[Image:1hnn.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)==
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The line below this paragraph, containing "STRUCTURE_1hnn", creates the "Structure Box" on the page.
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<StructureSection load='1hnn' size='340' side='right'caption='[[1hnn]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hnn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HNN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SKF:1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-SULFONIC+ACID+AMIDE'>SKF</scene></td></tr>
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{{STRUCTURE_1hnn| PDB=1hnn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnn OCA], [https://pdbe.org/1hnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hnn RCSB], [https://www.ebi.ac.uk/pdbsum/1hnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hnn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hnn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hnn ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)===
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==See Also==
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*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11591352}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11591352 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11591352}}
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==Disease==
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Known disease associated with this structure: Hypertension, essential, 145500 (1) OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=171190 171190]]
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==About this Structure==
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1HNN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNN OCA].
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==Reference==
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Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT., Martin JL, Begun J, McLeish MJ, Caine JM, Grunewald GL, Structure. 2001 Oct;9(10):977-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11591352 11591352]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phenylethanolamine N-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Begun J]]
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[[Category: Begun, J.]]
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[[Category: Caine JM]]
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[[Category: Caine, J M.]]
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[[Category: Grunewald GL]]
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[[Category: Grunewald, G L.]]
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[[Category: Martin JL]]
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[[Category: Martin, J L.]]
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[[Category: McLeish MJ]]
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[[Category: McLeish, M J.]]
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[[Category: Adrenaline synthesis]]
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[[Category: Methyltransferase]]
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[[Category: S-adenosyl methionine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:26:27 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN PNMT COMPLEXED WITH SK&F 29661 AND ADOHCY(SAH)

PDB ID 1hnn

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