1hr6

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{{Seed}}
 
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[[Image:1hr6.png|left|200px]]
 
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<!--
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==Yeast Mitochondrial Processing Peptidase==
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The line below this paragraph, containing "STRUCTURE_1hr6", creates the "Structure Box" on the page.
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<StructureSection load='1hr6' size='340' side='right'caption='[[1hr6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hr6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HR6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1hr6| PDB=1hr6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hr6 OCA], [https://pdbe.org/1hr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hr6 RCSB], [https://www.ebi.ac.uk/pdbsum/1hr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hr6 ProSAT]</span></td></tr>
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</table>
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===Yeast Mitochondrial Processing Peptidase===
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== Function ==
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[https://www.uniprot.org/uniprot/MPPA_YEAST MPPA_YEAST] Cleaves presequences (transit peptides) from mitochondrial protein precursors. The cleavage sites typically contain an arginine at position -2 (in the N-terminal portion) from the scissible peptide bond in addition to other distal basic residues, and an aromatic residue at position +1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11470436}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11470436 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/1hr6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11470436}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HR6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HR6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hr6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences., Taylor AB, Smith BS, Kitada S, Kojima K, Miyaura H, Otwinowski Z, Ito A, Deisenhofer J, Structure. 2001 Jul 3;9(7):615-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11470436 11470436]
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</StructureSection>
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[[Category: Mitochondrial processing peptidase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Deisenhofer, J.]]
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[[Category: Deisenhofer J]]
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[[Category: Ito, A.]]
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[[Category: Ito A]]
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[[Category: Kitada, S.]]
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[[Category: Kitada S]]
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[[Category: Kojima, K.]]
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[[Category: Kojima K]]
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[[Category: Miyaura, H.]]
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[[Category: Miyaura H]]
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[[Category: Otwinowski, Z.]]
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[[Category: Otwinowski Z]]
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[[Category: Smith, B S.]]
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[[Category: Smith BS]]
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[[Category: Taylor, A B.]]
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[[Category: Taylor AB]]
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[[Category: Hxxeh zinc-binding motif]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:34:23 2008''
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Current revision

Yeast Mitochondrial Processing Peptidase

PDB ID 1hr6

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