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1huc

From Proteopedia

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{{Seed}}
 
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[[Image:1huc.png|left|200px]]
 
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==THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY==
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The line below this paragraph, containing "STRUCTURE_1huc", creates the "Structure Box" on the page.
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<StructureSection load='1huc' size='340' side='right'caption='[[1huc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1huc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HUC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1huc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1huc OCA], [https://pdbe.org/1huc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1huc RCSB], [https://www.ebi.ac.uk/pdbsum/1huc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1huc ProSAT]</span></td></tr>
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{{STRUCTURE_1huc| PDB=1huc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1huc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1huc ConSurf].
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<div style="clear:both"></div>
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===THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY===
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_1868826}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1868826 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1868826}}
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==About this Structure==
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1HUC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUC OCA].
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==Reference==
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The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity., Musil D, Zucic D, Turk D, Engh RA, Mayr I, Huber R, Popovic T, Turk V, Towatari T, Katunuma N, et al., EMBO J. 1991 Sep;10(9):2321-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1868826 1868826]
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[[Category: Cathepsin B]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Musil, D.]]
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[[Category: Musil D]]
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[[Category: Thiol protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:41:12 2008''
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Current revision

THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY

PDB ID 1huc

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