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1hyg

From Proteopedia

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{{Seed}}
 
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[[Image:1hyg.png|left|200px]]
 
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==Crystal structure of MJ0490 gene product, the family of lactate/malate dehydrogenase==
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The line below this paragraph, containing "STRUCTURE_1hyg", creates the "Structure Box" on the page.
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<StructureSection load='1hyg' size='340' side='right'caption='[[1hyg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HYG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_1hyg| PDB=1hyg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyg OCA], [https://pdbe.org/1hyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hyg RCSB], [https://www.ebi.ac.uk/pdbsum/1hyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hyg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDH_METJA MDH_METJA] Catalyzes the reversible oxidation of malate to oxaloacetate. Also catalyzes the reduction of sulfopyruvate, but not pyruvate, nor alpha-ketoglutarate. Higher selectivity for the coenzyme NADPH.<ref>PMID:10850983</ref> <ref>PMID:10998181</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hyg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hyg ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of MJ0490 gene product, the family of lactate/malate dehydrogenase===
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==See Also==
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11292347}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11292347 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11292347}}
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==About this Structure==
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1HYG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYG OCA].
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==Reference==
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Crystal structure of the MJ0490 gene product of the hyperthermophilic archaebacterium Methanococcus jannaschii, a novel member of the lactate/malate family of dehydrogenases., Lee BI, Chang C, Cho SJ, Eom SH, Kim KK, Yu YG, Suh SW, J Mol Biol. 2001 Apr 13;307(5):1351-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11292347 11292347]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Chang C]]
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[[Category: Chang, C.]]
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[[Category: Cho S-J]]
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[[Category: Cho, S J.]]
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[[Category: Lee BI]]
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[[Category: Lee, B I.]]
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[[Category: Suh SW]]
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[[Category: Suh, S W.]]
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[[Category: Nucloetide binding domain]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:07:36 2008''
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Current revision

Crystal structure of MJ0490 gene product, the family of lactate/malate dehydrogenase

PDB ID 1hyg

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