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1hzw

From Proteopedia

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{{Seed}}
 
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[[Image:1hzw.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE==
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The line below this paragraph, containing "STRUCTURE_1hzw", creates the "Structure Box" on the page.
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<StructureSection load='1hzw' size='340' side='right'caption='[[1hzw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HZW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1hzw| PDB=1hzw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hzw OCA], [https://pdbe.org/1hzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hzw RCSB], [https://www.ebi.ac.uk/pdbsum/1hzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hzw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/1hzw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hzw ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE===
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11316879}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11316879 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11316879}}
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==About this Structure==
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1HZW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZW OCA].
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==Reference==
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Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP., Almog R, Waddling CA, Maley F, Maley GF, Van Roey P, Protein Sci. 2001 May;10(5):988-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11316879 11316879]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Thymidylate synthase]]
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[[Category: Almog R]]
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[[Category: Almog, R.]]
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[[Category: Maley F]]
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[[Category: Maley, F.]]
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[[Category: Maley GF]]
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[[Category: Maley, G F.]]
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[[Category: Van Roey P]]
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[[Category: Roey, P Van.]]
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[[Category: Waddling CA]]
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[[Category: Waddling, C A.]]
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[[Category: Human]]
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[[Category: Open conformation]]
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[[Category: Thymidylate synthase]]
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[[Category: Uncomplexed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:12:02 2008''
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Current revision

CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE

PDB ID 1hzw

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